Background: Rotavirus gastroenteritis (RVGE) is a significant cause of under-5 morbidity and mortality in the developing world. This study investigates the cost-effectiveness of adopting a national infant immunization program against RVGE in Nigeria. Methods: A spreadsheet model combined demographic, epidemiological, utilization and economic data on order to calculate the cost per disability adjusted life years (DALY) averted due to various vaccination programs. Results: Total costs of vaccinating 70% of a birth cohort would be $47 million (pentavalent Rotateq 3RV5), $19million and $28 million (two and three doses of monovalent Rotarix,2RV1,3RV1) of which only around 4% are recovered
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